2025 Summer Intern-Translational Safety (roche)

Job Description

Department Summary

Development Sciences (DevSci) is a translational science organization that spans the entire drug discovery and development cycle — from early stage research to drug commercialization. Part of the drug development pipeline in DevSci includes the preclinical safety evaluation of therapeutic candidates by scientists, toxicologists and pathologists in the Translational Safety (TS) department in order to enable further evaluation in humans.

The complex in vitro systems lab (CIS) within TS develops and characterizes models that have the potential to reduce or replace the use of animals in the assessment of efficacy, biodistribution and toxicity. CIS works closely with scientists across DevSci and Genentech/ Roche broadly to develop, democratize, and prioritize complex in vitro models and to interpret data generated with them towards this goal. Using a variety of genetic, functional, and morphological assessments in collaboration with pathologists, image analysis scientists, and computational scientists, CIS aims to provide high quality toxicology data that helps to derisk and/or understand the clinical relevance of potential adverse drug reactions. 

This internship position is located in South San Francisco, on-site

The Opportunity

A position is available to assist our team in the characterization of models of the lung and/or brain using a combination of histology, ultrastructure, immunoreactivity, and digital pathology algorithms. You will work closely with pathologists, image analysis scientists, and lab-based scientists to compare the features of simple and complex in vitro models to the “ground truth” of in vivo (human or animal) tissue samples. You will use commercially available image analysis platforms to generate ground truth and assist in developing methods to provide quantitative data that will be correlated with orthogonal assessments of model structure, function, and xenobiotic sensitivity. 

Program Highlights

•  Intensive 12-weeks (40 hours per week) paid internship.

• Program start dates are in May/June (Summer)

• A stipend, based on location, will be provided to help alleviate costs associated with the internship. 

• Ownership of challenging and impactful business-critical projects.

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• Work with some of the most talented people in the biotechnology industry. 

Who You Are (Required)

Required Education: - Must be pursuing a Master's Degree (enrolled student).

Required Majors: Histopathology or related

Required Skills:

• Experience with microscopy, histology, and/or anatomic pathology

• Basic understanding of comparative physiology

• Ability to read and accurately summarize scientific literature

• Enthusiasm to learn standard image processing and statistical analysis software

• A strong interest in working across disciplines with scientists in a variety of fields

• Desire to work closely with and help others

• Experience with commercially available or open-source image analysis software.

• Experience with immunohistochemistry, immunofluorescence, and/or immunogold staining techniques

• Although not required, interest and/or experience in computational approaches to image analysis, statistical analysis, and computer programming are a plus.

Preferred Knowledge, Skills, and Qualifications

• Excellent communication, collaboration, and interpersonal skills.

• Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.

Relocation benefits are not available for this job posting. 

The expected salary range for this position based on the primary location of  California is $35-$45hour.  Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits.

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