2025 U.S Summer Internship Program: Cell Therapy Process Development Intern (takeda)

Job Description

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Job Description

The Cell Process Development team operates as the bridge between early discovery and manufacturing by developing large-scale processes for our cell therapy projects. We work closely with our Drug Discovery Units, early CMC, and manufacturing colleagues to produce manufacturing-ready cell therapy processes.

Job Description:

The progression of cell therapy research projects into large-scale procedures is an important step in developing a successful and profitable product. It is essential for initial studies to identify and test potential pain points and de-risk procedures for the smooth transition into Manufacturing. Changes in constructs and procedures during early discovery may improve the product at small-scale, however it is necessary to investigate the changes with large-scale protocols.

Our Discovery team has made exciting changes to the cytokine armoring of a current project that has showed encouraging in vitro results. While results have been promising with the updated constructs, these studies have utilized a small-scale transduction method that may not translate to large-scale manufacturing processes. The intern will:

• Investigate the large-scale transduction step for the new lead constructs
• Determine the optimal conditions for large-scale transduction using a more translatable transduction method
• Several parameters of the transduction step will be investigated using a combination of a scaled-down transduction technique and the full large-scale transduction method.
   

Internship Development Opportunities:

• Gain understanding of cell therapy field and role of Process Development

• Gain broad understanding of γδ T cells and project background

• Gain understanding of γδ T cell large-scale expansion processes

• Understand the study objectives including rationale and experimental planning

• Develop general lab skills and learn process development workflows including cell counting, cell isolation and depletion, transduction, expansion, and harvest

• Gain understanding of and experience in flow cytometry

Job Requirements:

• This position will be Fully Onsite and require 4+ days in the Cambridge, MA office per week.
• Must be pursuing a Bachelor’s Degree in Biology, Biomedical Engineering, or related field
• Have basic aseptic technique training
• Hands-on wet lab experience including mammalian cell culture
• General knowledge of cell biology and immunology
• Experience working with primary cells
• Knowledge of cell therapy field including CAR T cell therapy
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• Knowledge of viral vector transduction
• Basic understanding of computer skills including MS Office (PowerPoint, Words, Excel)
• Internet skills including use of e-mails, group messaging and information gathering
• Highly reliable and a strong team player
• Flexible with an attention to detail
• Strong verbal and written communication skills

Internship Eligibility

• Must be authorized to work in the U.S. on a permanent basis without requiring sponsorship
• Must be currently enrolled in a degree program graduating December 2025 or later
• The internship program is 10-12 weeks depending on the two start dates (June 2nd- August 29th) or (June 16th - August 22nd)
  • The intern must be able to commit to one of these time frames
• Able to work full time 40 hours a week during internship dates
• Takeda does not provide a housing stipend or relocation support for the U.S Summer Internship Program

 Program Highlights:

• Hands-on experience with real projects and responsibilities
• Dedicated mentorship program pairing interns with experienced professionals
• Networking opportunities with industry professionals and fellow interns
• Internship events focused on professional and skills development
• Exposure to multiple business areas or departments within a Pharmaceutical Organization

Applications will be accepted between December 18th and January 10th

For Location:

U.S. Hourly Wage Range:

$21.00 - $46.00

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

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Job Exempt