2025 U.S Summer Internship Program: Early Cell Process Development Intern (takeda)

Job Description

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Job Description

The Early Chemistry, Manufacturing, Controls (CMC) process development group serves as the link between discovery and manufacturing for oncology programs. Our mission is to ensure that emerging projects are scalable, manufacturable, cost-effective, and efficacious for patients. We collaborate closely with the Drug Discovery Units (DDUs) and other CMC teams, bridging the gap between research and manufacturing.

Job Description:

The intern will work on a project to determine nutrient usage, byproduct accumulation, and cytokine uptake in gamma delta T (gdT) cells across large-scale, small manufacturing model, and bioreactor processes.

How You Will Contribute:

• Determine how media components are being used by gdT cells throughout manufacture across large-scale, small manufacturing model, and bioreactor processes
• Assess any differences across the processes
• Collaborate with Data and Automation teams to determine the impact of optimized nutrient availability and cytokine concentration using data obtained through a design of experiments approach (DoE) using a high-throughput system (HTS)
• Correlate variables to in-process data and functional readouts with the help of the Data team
• Assess top conditions in small manufacturing models

Internship Development Opportunities:

• Gain understanding of media composition and its importance to cell health, expansion, and final drug product quality/potency
• Understand how gdT cells use nutrients and cytokines throughout their expansion
• Understand what the effect of changing nutrient availability during expansion has on final drug product quality/potency
• Understand the gdT manufacturing processes and the relationship/crosstalk across manufacturing, scalable manufacturing models, and bioreactors
• Develop lab skills and learn process workflows: aseptic technique, cell culture, cell counting; cell isolation, transduction, expansion, harvest, cryopreservation
• Learn to communicate and work effectively in a cross-functional setting

Job Requirements:

• This position will be Fully Onsite and require 4+ days in the Cambridge office per week.
• Must be pursuing a Master’s or Doctoral Degree in a relevant Field of Study
• Experience with cell culture, aseptic technique, and lab safety
• Basic understanding of immunology
• Basic knowledge of statistics
• Prior experience in process development a plus
• Prior experience with automation a plus
• Prior experience with bioreactors a plus
• Basic understanding of computer skills including MS Office (PowerPoint, Words, Excel)
• Internet skills including use of e-mails, group messaging and information gathering
• Highly reliable and a strong team player
• Flexible with an attention to detail
• Strong verbal and written communication skills

Internship Eligibility

• Must be authorized to work in the U.S. on a permanent basis without requiring sponsorship
• Must be currently enrolled in a degree program graduating December 2025 or later
• The internship program is 10-12 weeks depending on the two start dates (June 2nd- August 22nd) or (June 16th - August 29th)
  • The intern must be able to commit to one of these time frames
• Able to work full time 40 hours a week during internship dates
• Takeda does not provide a housing stipend or relocation support for the U.S Summer Internship Program

 Program Highlights:

• Hands-on experience with real projects and responsibilities
• Dedicated mentorship program pairing interns with experienced professionals
• Networking opportunities with industry professionals and fellow interns
• Internship events focused on professional and skills development
• Exposure to multiple business areas or departments within a Pharmaceutical Organization

Applications will be accepted between January 6th and January 31st

For Location:

U.S. Hourly Wage Range:

$21.00 - $46.00

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

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Job Exempt